The Center of Microbiome and Inflammatory Disease (CMID) laboratory investigates the emerging and exciting field of
microbiome research that evaluates the factors which influence microbiota establishment in mammals. Since the ecology
of microbiota can affect health and disease susceptibility, this research could lead to therapies for chronic inflammatory
diseases such as inflammatory bowel disease (IBD), diabetes and obesity.
The intestinal microbiome includes a complex and diverse environment of microbes and their genetic material that interact intimately with the host mucosal-immune system. The microbiota normally lives in harmony with the intestine and plays a significant role in the development of intestinal immune responses in neonates. Compelling emerging evidence has identified the intestinal microbiome as a major factor contributing to the etiology of IBD; dysbiosis, or altered microbial populations, have been observed in patients with IBD. Any significant alterations made to the microbiota's ecology would likely have a significant impact on the hostís immune responses with wide- ranging biological consequences since components of the intestinal microbiome play a crucial role in the early development of both local and systemic immunity. To date, however, little is known about the evolution of an individualís microbiome or its role in health and disease. Understanding the dynamics of microbial population changes along with their transciptomes may offer insight into the role each population plays during intestinal homeostasis and disease. CMID investigates the intestinal microbiome and determine the contributing roles of environmental factors (with a focus on postnatal and maternal diets) and genetics. The research program aims to understand how the intestinal microbiome is affected by dietary and innate immune factors and in turn, how diet can protect against intestinal disease.
The overall hypothesis of the lab is that environmental factors, such as nutrition, physical activity, drugs and stress
influence the ecology and functioning of the intestinal microbiome, which alters disease susceptibility (Figure below).
Using animal models of IBD and type 1 diabetes we examine:
(i) The role of maternal and postnatal dietary influence on altering the intestinal
microbiome, innate immune responses,and susceptibility to IBD.
(ii) The role of innate immunity on controlling the ecology and functioning of the
intestinal microbiome, and how this relates to host susceptibilities to IBD.
(iii) The potential for therapeutic approaches in correcting microbiome 'deficiencies'
using probiotics to influence colonization and altering disease risk.
(iv) How drugs interact with the microbiome and protect against chronic inflammation
(v) The role of the microbiome and intestinal inflammation in type 1 diabetes onset
Intestinal Disease Education & Awareness Society (IDEAS)
Canadian Foundation for Innovation
Canadian Association of Gastroenterology
Child and Family Research Institute Diabetes Group
Juvenile Diabetes Research Foundation
2010-2011 Intestinal Disease and Education Awareness Society Website and facebook sitehttp://www.facebook.com/weneedideas
April 6, 2011 "UBC study: Microbiota fend off intestinal infections" by Bud Mortensenhttps://news.ok.ubc.ca/2011/04/06/ubc-study-microbiota-fend-off-intestinal-infections/
April 11, 2011 "Undergrad size ="4"uate wins research award" by Deanna Robershttpwww.ubc.ca/okanagan/ikbarberschool/Jessica_Baker.html?PageMode=Edit